Clay Grayson

Contact Clay
Office: 843.268.4889
Direct: 843.603.5884

Recognized by Best Lawyers in the categories of “Nonprofit/ Charities Law” and “Business Organizations (including LLCs and Partnerships),” Clay M. Grayson has built a law practice dedicated to provide external general and special counsel services primarily to nonprofit organizations as well as businesses and entrepreneurs dedicated to the advancement of technology.

Clay has extensive experience in federal taxation of exempt organizations, not-for-profit corporate governance, public private partnerships, executive compensation, unrelated business income tax, charitable and planned giving, and joint ventures. A significant amount of his practice is dedicated to foundations that support universities, colleges, and schools, including endowment foundations, research foundations, real estate foundations, alumni associations, and athletic booster clubs.

Clay counsels hospitals, academic medical centers, foundations, and universities on leading edge health industry relationship formation and realignments, with a focus on health information technology acquisitions; electronic health information network strategy, development, and implementation to support innovations in care, delivery, and payment models; translational research; personalized medicine; health information exchanges; clinical data warehouses; industry sponsored research; issues related to institutional review boards; technology transfer; and comprehensive programs for human subject, animal and bench research.

Clay also represents several national software and IT developers and licensors that service a variety of industries, including e-commerce, data analytics and processing, insurance, healthcare, academics, and advanced computing.

In addition to his J.D., Clay has a Masters in International Business Studies from the University of South Carolina, and an L.L.M. in Taxation from New York University. Prior to the practice of law, Mr. Grayson worked in the marketing department of the Italian subsidiary of Merck pharmaceuticals, where he assisted in the launch of new products in Europe.


  • South Carolina
  • U.S. Tax Court
  • U.S. Court of Appeals, Fourth Circuit


  • LL.M., New York University
  • J.D., University of South Carolina
  • Master in International Business Studies, University of South Carolina
  • Certificate, Bocconi, Milan, Italy (Italian/European Business, S.D.A.)
  • B.A., College of Charleston (with honors)


  • Recognized by Best Lawyers in “Nonprofit/ Charities Law” and “Business Organizations (including LLCs and Partnerships),” 2017-2023
  • Selected for Charleston Regional Business Journal’s “Forty Under 40,” 2012
  • Named as one of “The Rising Stars” by South Carolina Super Lawyers magazine, 2012 - 2014
  • Member of Leadership Charleston, Class of 2008

Professional/Civic Activities

  • American Bar Association, Member
  • American Health Lawyers Association, Member
  • Hollings Cancer Center Advisory Citizens Council, Member
  • SC Planned Giving Council, Director
  • Charleston Jazz, Director and Secretary
  • Charleston Tax Council, Member
  • Together SC, formerly known as South Carolina Association of Nonprofit Organizations - pro bono general counsel, volunteer, past Board member.